The German Consortium for Translational Cancer Research (DKTK) is a center of excellence dedicated to identify new therapeutic and diagnostic options. The focus at the Frankfurt/Mainz site is on cell and immunotherapy, where patient-specific immune cells are modified to specifically recognize and kill tumor cells. In diagnostics, methods to study the tumor proteome are used to complement genetic approaches. DKTK Frankfurt collaborates closely with the Goethe University and other partner institutions to improve the quality of patient care.